Posts for: September, 2013
Does gum disease indicate future joint problems? Although researchers and clinicians have long known about an association between two prevalent chronic inflammatory diseases - periodontal disease and rheumatoid arthritis (RA) - the microbiological mechanisms have remained unclear.
In an article published in PLoS Pathogens, University of Louisville School of Dentistry Oral Health and Systemic Diseases group researcher Jan Potempa, PhD, DSc, and an international team of scientists from the European Union's Gums and Joints project have uncovered how the bacterium responsible for periodontal disease, Porphyromonas gingivalis worsens RA by leading to earlier onset, faster progression and greater severity of the disease, including increased bone and cartilage destruction.
The scientists found that P. gingivalis produces a unique enzyme, peptidylarginine deiminanse (PAD) which then enhances collagen-induced arthritis (CIA), a form of arthritis similar to RA produced in the lab. PAD changes residues of certain proteins into citrulline, and the body recognizes citullinated proteins as intruders, leading to an immune attack. In RA patients, the subsequent result is chronic inflammation responsible for bone and cartilage destruction within the joints.
Potempa and his team studied another oral bacterium, Prevotella intermedia for the same affect, but learned it did not produce PAD, and did not affect CIA.
"Taken together, our results suggest that bacterial PAD may constitute the mechanistic link between P. gingivalis periodontal infection and rheumatoid arthritis, but this ground-breaking conclusion will need to be verified with further research," he said.
Potempa said he is hopeful these findings will shed new light on the treatment and prevention of RA.
Studies indicate that compared to the general population, people with periodontal disease have an increased prevalence of RA and, periodontal disease is at least two times more prevalent in RA patients. Other research has shown that a P. gingivalis infection in the mouth will precede RA, and the bacterium is the likely culprit for onset and continuation of the autoimmune inflammatory responses that occur in the disease.
***ARTICLE TAKEN DIRECTLY FROM MEDICAL NEWS TODAY***
It is that time of year once again, back to school. And while we may be going crazy with all the excitement the year will bring our children we cannot over look their dental care.
Your child may have the latest wardrobe, school supplies and sports equipment for the new school year, but does she have a healthy mouth and the tools she'll need to maintain it?
According to the American Dental Association, a dental examination is as important as immunizations and booster shots and should be a regular part of back-to-school preparations. Statistics from the Centers for Disease Control and Prevention say that tooth decay affects U.S. children more than any other chronic infectious disease and 19 percent of children ages 2 to 19 years old have untreated tooth decay. Dental pain or disease can lead to difficulty in eating, speaking, playing and learning as well as millions of hours of missed school.
Your child's back-to-school checklist should include:
• Regular dental examinations to diagnose and treat or prevent dental problems. Parents and teachers may not realize there's a dental problem, so regular checkups are important. Your dentist may suggest fluoride treatments or sealants to prevent decay and can diagnose and treat dental problems to save your child pain and lost school time.
• Regular brushing with fluoride toothpaste and flossing. Head for the dentalcare isle when you're out shopping for notebooks, binders and pencils. If parents buy several toothbrushes they could have their child change to a new one every three months or so, or after an illness. If it's hard to remember when to change a brush, you could try to change it every time report cards come out. Ask your dentist for a recommendation on how often to change toothbrushes.
• Eating healthy lunches and snacks. Include portable healthy lunch items and snacks in your child's sack lunch, including grains, milk, cheese, raw vegetables, yogurt or fruit. If your child eats in the school cafeteria, review healthy, balanced food choices with him before the first day of school. Cut back on sugary foods and soft drinks.
• Wearing a properly fitted mouthguard while participating in organized sports, PE classes or playground activities.
For more dental health tips, log on to ADA.org and browse through the Oral Health Topics list.
*** Article taken directly from the ADA website***